Project Description

Fresco Clinical Research Grants

Request for Applications (RFA)

The Marlene and Paolo Fresco Institute for Parkinson’s and Movement Disorders at NYU Langone Health (FI-NYU) is seeking applications to support promising collaborations to advance our understanding of clinical care for Parkinson’s disease (PD) and to encourage clinician scientists to pursue research into advancing clinical care with specific relevance for Parkinson’s patients in Italy. A central goal of FI-NYU is to help develop and support the medical and scientific community in Italy working in this field. Our Clinical Research Grants Program is specifically focused on advancing our understanding of the clinical outcomes of innovative and best care practices for Parkinson’s disease at Italian Movement Disorder Centers thathave been designated Fresco Network Centers (a “Center”).

The Fresco Network (FN) is supported by the USA-Italy Bridge program with the vision to deliver improved patient outcomes by bringing together Italian and American best practices in the science of medicine. In our efforts to realize this goal, this grant program will be administered by the FI-NYU but will fund research conducted in Italy exclusively. Each Fresco Clinical Research Grant will provide $200,00 (USD) support for up to three years of funding for a Center director or another researcher under the supervision of the center director.

We encourage multi-site applications reflecting research collaboration across the FN or between a Center and a non-FN institution to follow the spirit of the Fresco Network.

Focus Areas

Applications may request research support for any of the following focus areas:

  1. Sub-study under the Parkinson’s Outcomes Project (“POP”). For any center participating in the POP, an application may propose to add an interventional or observational study of subjects in that cohort. Note that the proposed study should not result in a modification of the POP protocol but only add additional study-related activities and that the application budget should cover all costs not currently covered by POP.
  2. Impact of art and/or music therapy in Parkinson’s care. The application can study clinical or physiological changes and therapy may be considered alone or adjunctive to other interventions.
  3. Impact of exercise, rehabilitation modalities, and/or virtual reality therapy in Parkinson’s care. Applications can study clinical and/or physiological impact. Applications should address impact on balance, proprioception, vestibular system changes, functional changes, and should describe how these will be measured (or if not addressed, why).

This RFA is open to FN Center investigators only. Either the center director or a researcher under the supervision of the center director (“Applicant”) are eligible to apply. Investigators from the Center’sparent institution or affiliated institutions are eligible, however, the center director will be responsible for the conduct of the research and use of funds. If the project will be a multi-center project, a principal investigator from an FN Center should be designated.

FI-NYU will award up to two Fresco clinical research grants. Applications must meet the following criteria:

The Applicant must meet eligibility criteria and apply to conduct research in one of the specified focus areas.

The Applicant must dedicate 15% or more of his or her full-time effort to the research. Applications will be evaluated based on assessment of the following criteria:

  • Academic and scientific excellence of the proposed research;
  • Alignment of the proposed research to the identified focus area;
  • Track record of the research team in completing high-quality, high-impact research, and authorship of well-regarded scientific papers;
  • An achievable, rigorous research plan for three years or less that, if successful, will impact clinical care for Parkinson’s disease and will lead to new avenues of clinical and pre-clinical investigation;
  • An institutional environment conducive to the proposed research program.Grants will be made as supplemental awards to the Center’s FN award with funds required to be disbursed according to the approved budget. Each grant is $200,000 (USD) and funds will be dispersed on an annual basis to each center subject to continued satisfactory performance as assessed from annual progress reports submitted by the awardee to FI-NYU. The funds can be used to provide salary support as well as support for the awardee’s research supplies, equipment, or other research needs. No indirect costs or overhead will be paid from the grant. The first payment will be sent upon return of the executed grant award agreement. If the proposed work can no longer be carried out by the awardee, such as the departure of a named investigator, FI-NYU reserves the right to require the return of any unpaid grant funds, to be detailed in the grant award agreement. All the funds need to be utilized in Italy exclusively.Awardees will be required to submit annual progress reports and an institutional financial statement to FI-NYU. The annual report must be sufficiently detailed for FI-NYU to assess the progress against milestones, research findings, and use of funds.

Research Plan

  1. Specific Aims (1 page);
  2. Background and significance of the proposed work, including its relevance to and potential impact (1-2 pages);
  3. Detailed explanation of experiments proposed, hypotheses to be tested, and anticipated results (3-4 pages).

Page Limits: 8


  1. Narrative budget justification (salary support, supplies, equipment, and other expenses);
  2. Annual budgets.

Page Limits: 2

Applicant and research team

  • Brief descriptions of the Applicant and members of the research team.

Page Limits: 2

Institutional Support Letter

The institution must provide a statement that includes:

1. Description of research facilities, equipment, resources, and training available to support the proposed research;

2. Approval of the budget.

Page Limits: 2

Curriculum Vitae

Applicant CV, including education, research positions, publications, and other relevant professional history

Page Limits: 4

Letters of support

Include any letters of support necessary to strengthen the application. If necessary, such letters should allay reviewer concerns about feasibility, such as regarding access to facilities or ability to meet recruitment goals.

Page Limits: 1 per letter

  • Application Deadline:

    September 30, 2019

    Applicants are encouraged to submit applications before the due date. Applications should be submitted in English. Applicants are responsible for reviewing their application for accuracy and completeness prior to submission.

  • Review and Selection Process:

    All applications will undergo an administrative and scientific review by a committee appointed by the NYU-FI leadership, which also considers overall funder priorities.

    The evaluation will be based on the criteria noted above.

  • Anticipated Announcement and Award Dates:

    We anticipate announcing awards

    six weeks after the submission deadline.

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